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APNASPENAspen Pharmacare Hldgs15842368 (2.38%)

Aspen is in a closed period from 1st July 2026 until the publication of the annual results on the JSE SENS platform on the 2nd September 2026.

Aspen signs R10 billion deal with MSD

Oss, Netherlands – JSE Limited listed Aspen Holdings is pleased to announce that the Aspen Group (“Aspen”), the ninth largest generic pharmaceutical company in the world, has: signed an agreement with MSD (known as Merck in the United States and Canada) for the acquisition of an active pharmaceutical ingredient (“API”) manufacturing business which manufactures for MSD and the market generally and which is located in the Netherlands with a satellite facility and sales office in the US (“the API Business”); and reached an agreement on an option to acquire a portfolio of 11 branded finished dose form molecules (“the Products”) from MSD, covering a diverse range of therapeutic areas and including products that use APIs manufactured by the API Business. (collectively “the Transaction”) Stephen Saad, Aspen Group Chief Executive, said “One of Aspen’s primary strategic intents is to further globalise its business, increase its representation across a number of additional territories and provide support to its growing global presence with a differentiated pipeline. This Transaction provides a platform to contribute to the achievement of this strategic intent by enabling Aspen to access a niche range of APIs and finished dosage products.” The Transaction, which is subject to conditions precedent, is valued at approximately US$1 billion (ZAR10.06 billion at ZAR10.06/US$) and comprises the following elements: In respect of the API business: Aspen Holdings will acquire the shares of a new Dutch company (“Dutch Newco”) containing the API Business for a consideration of approximately €36 million (ZAR472 million at ZAR13.11/€); and Dutch Newco will simultaneously acquire inventory with an expected value of approximately €300 million (ZAR3.9 billion at ZAR13.11/€). In respect of the Products: Aspen Global Incorporated, a wholly owned subsidiary of Aspen Holdings, has the option to acquire the Products by way of the exercise of a call option with a resulting asset purchase for a consideration of US$600 million. The effective date of the API Business acquisition is expected to be 1 October 2013 while the expected effective date of the Products acquisition through the exercise of the option is 31 December 2013. Funding: The Transaction, other than certain deferred payments for the MSD inventory and the Products, will be funded from new debt facilities which are at an advanced stage of negotiation. It is planned to fund the deferred payments from Aspen’s existing cash at the time payment is due. The API Business: The API Business consists of manufacturing operations within existing MSD sites comprised as follows: In Oss, the Netherlands, parts of the Moleneind and De Geer sites as well as the entire Boxtel site; and Sioux City, Iowa, in the US. The business also has sales offices at the Oss site in the Netherlands and in Des Plaines, Illinois, in the US. The products manufactured at the sites fall into two categories, namely biochemicals, where biological processes are involved, and chemicals where the process is fully synthetic. The API Business recorded pro-forma revenue of €284 million in the year ended 31 December 2012. The Products: The Products comprise a portfolio of 11 branded finished dosage form molecules, covering a diverse range of therapeutic treatments. The main brands being acquired, by therapeutic area, are: Therapeutic Category Brands Hormone replacement therapy Ovestin, Sustanon, Metrigen Anti-Coagulant Oragan Cortico-Steroid Decadron, Oradexon, Metricorten, Meticortelone Anabolic steroid Deca Durabolin Hyperthyroidism Thyrax, Strumazol Oral Contraceptives Gracial, Novial Vitamin B Complex Benutrex MSD reports that the products which are the subject of the transactions recorded revenue of US$ 248 million in its financial year ended 31 December 2012. More than half of this revenue was generated in Aspen’s key strategic regions of Latin America and Asia Pacific with Europe being the other large territory. The Products will be initially manufactured under the pre-existing MSD manufacturing arrangements in terms of a medium term supply agreement between Aspen Global Incorporated and MSD. Rationale: The following considerations support the rationale for the Transaction: The API Business manufactures heparin, the API used in the manufacture of Fraxiparine, one of the products for which Aspen has made an offer to GSK (refer to Aspen’s cautionary announcement of 18 June 2013); The API Business manufactures the APIs used in a number of the products Aspen will be acquiring under the Transaction, allowing for effective vertical integration; MSD will continue to acquire APIs from Aspen under a 10-year supply contract which will provide significant on-going volumes for the API Business; Aspen plans to improve the cost competitiveness of the APIs; There are opportunities for Aspen to develop finished dosage form products from certain of the APIs such as hormones and peptides; The Products will complement Aspen’s existing portfolio and will provide critical mass to the Aspen offering in a number of markets. This will allow for additional promotional impetus to Aspen’s portfolio of global brands; and These niche Products will substantially supplement Aspen’s growing footprint in a number of emerging and established markets – the notable presence of these products in Latin America and Asia Pacific is supportive of Aspen’s aspirations for these regions.

Renewal of Cautionary Announcement

APN – Aspen Pharmacare Holdings Limited – Trading statement Aspen Pharmacare Holdings Limited (Incorporated in the Republic of South Africa) (Registration number 1985/002935/06) Share code: APN & ISIN: ZAE000066692 (“Aspen”) Renewal of Cautionary Announcement Shareholders are referred to the renewal cautionary announcement released by Aspen on 7 March 2013 in which shareholders were advised of discussions between Aspen and MSD (known as Merck in the United States and Canada) in respect of a possible transaction comprising the acquisition of an active pharmaceutical ingredient facility situated primarily in the Netherlands and a related portfolio of pharmaceutical finished dose form products. These discussions remain ongoing and may have a material effect on the price of Aspen’s securities if successfully concluded and accordingly shareholders are advised to continue exercising caution when dealing in Aspen’s securities. Durban 23 April 2013 Sponsor: Investec Bank Limited

Aspen to invest more than R1,9 billion in infant nutritional deal with Pfizer

Shareholders of Aspen Holdings are advised that Aspen Group companies (“Aspen”) have concluded agreements with Nestlé S.A. in respect of the acquisition of certain rights to intellectual property licenses, net assets and shares in the IN businesses presently conducted by Pfizer which distribute a portfolio of IN products in Australia (the “Australian IN business”) and certain Southern African territories (South Africa, Botswana, Namibia, Lesotho, Swaziland and Zambia)(the “Southern African IN business”) for a total purchase consideration of USD 215 million. The IN portfolio covers all age stages (infants, toddlers and early childhood) and consists of premium, specialty and standard ranges supported by strong umbrella brands including S26 Gold®, S26® and SMA®. The revenue for the Australian and Southern African IN businesses amounted to AUD 83 million and ZAR 180 million respectively in 2012. Stephen Saad, Aspen Group Chief Executive said, “These transactıons support Aspen’s stated ambıtıons to extend our ınfant nutrıtıonal busıness. We understand the potentıal of these products as we are famılıar wıth the brands havıng marketed these ın South Afrıca under lıcense ın the recent past.” The Australian competition authorities have approved Aspen’s acquisition of the Australian IN business and the transaction will be effective in Australia from 28 April 2013. The South African and Namibian competition authorities’ approval of the acquisition of the Southern African IN business is pending. The nature of the transaction and the assets relating thereto are set out below: Aspen will have the exclusive right of use of the Nestlé (previously Pfizer) S26® and SMA® IN product trademarks for a period of 10 years (“licensed products”) in Australia and Southern Africa; Aspen will also have the right to co-brand the licensed products over the initial 10 year period and to transition these products to Aspen branded products over this period; For a further 10 year period, commencing after expiration of the initial 10 year exclusive licence period, Nestlé will be precluded from commercialising the licensed products (so-called “10 year black out period”), effectively providing Aspen with a 20 year period to establish equivalent Aspen branded IN products; Aspen will have a perpetual licence to the IN technology, technical know-how and formulations existing at the effective date plus access to an agreed licensed product pipeline together with related technology developments for a period of 5 years from the effective date; There will be a transfer of the ownership in the operating businesses from Nestlé to Aspen and this will include the transfer of the employees within those businesses; and Aspen will be provided with transitional service arrangements by Nestlé and Pfizer including the manufacture and supply of licensed products under a non-exclusive arrangement. These arrangements will provide Aspen with the flexibility to transition the manufacture of IN products to its own sources of supply including to its own IN manufacturing facilities within a 3 year period. The transaction presents a good commercial and strategic fit for Aspen, given its heritage with these brands and its strength in the IN market in South Africa coupled with its local manufacturing capabilities. In Australia the transaction will synergistically augment Aspen’s strong presence in the grocery and over-the-counter market segments. The transaction will provide Aspen with an enhanced platform from which to extend the global footprint of it’s IN business in the medium term.

Aspen increases revenue to R9 billion

JSE Limited listed Aspen Pharmacare Holdings Limited (Apn), the ninth largest generic company in the world and Africa’s largest pharmaceutical manufacturer, has announced excellent results for the interim period ended 31 December 2012. Group Performance Revenue from continuing operations increased by 20% to R9.0 billion. Operating profit from continuing operations rose by 24% to R2.5 billion. Normalised headline earnings, being headline earnings adjusted for restructuring costs, transaction costs and foreign exchange movements on transaction accounting, advanced by 24% to R1.7 billion. Normalised diluted headline earnings per share was 23% higher at 379 cents. Stephen Saad, Aspen Group Chief Executive said, “The Group’s favourable results were achieved by a combination of organic growth, contributions from acquisitions and successful new product launches. There are initiatives underway to extend Aspen’s proud growth record in all business segments. ” South African Business The South African business maintained the favourable momentum from the second half of the prior year, raising revenue by 23% to R3.6 billion and improving operating profit before amortisation, adjusted for specific non-trading items (“EBITA”), by 14% to R960 million. Revenue in the Pharmaceutical division increased by 24%, buoyed by ongoing organic growth, positive performances from new product launches and a strong upswing in anti-retrovirals (“ARVs”) sold under the public sector tender. Higher priced raw materials due to the weakening Rand and a greater weighting towards low margin ARVs resulted in margins in the Pharmaceutical division tightening despite production efficiency gains. The Consumer division increased revenue by 17%, led by impressive advances from Infacare, Aspen’s leading infant milk formula brand. Consumer margins were also negatively affected by the higher costs of imports. Capital projects are underway at each of the Group’s South African manufacturing sites to add capacity and advance technologies available as part of Aspen’s enduring aim to lower cost of goods. The Aspen Board of Directors has recently authorised a new project for the construction of two high containment suites, one for hormonals and one for oncolytics, on the Port Elizabeth site. The suites are for oral solid dose products requiring containment due to the risks associated with long-term exposure to these drugs during manufacture. Asia Pacific Business The Asia Pacific business maintained its record of continuous growth, lifting revenue by 18% to R3.4 billion and growing EBITA by 29% to R949 million. Revenue growth was achieved in Australia, the dominant contributor to this territory, despite mandatory price cuts imposed by the regulator. A key growth driver was new products secured through acquisitions. Revenue from Aspen’s products in Asia also continued to grow. Margins widened as the programme of cost of goods savings produced additional benefits. The strengthening of local currencies relative to the Rand enhanced results. The consolidation and rationalisation of Australia’s manufacturing facilities progressed further with the decision reached to close the Baulkham Hills site. Once complete, all Australian manufacture will be concentrated on the Dandenong site. International Business The International business increased revenue by 22% to R1.8 billion and expanded EBITA by 33% to R604 million. The Latin American region was the greatest contributor to the revenue advancement due to a combination of organic and acquisitive growth. In line with Aspen’s objective of extending its footprint in Latin America, a subsidiary was established in Argentina during the period. In addition to the revenue growth achieved in this territory, EBITA was also lifted by improved margins delivered by the global brands portfolio. Sub-Saharan Africa business Gross revenue from Sub-Saharan Africa was up by 19% at R1.0 billion as greater promotional activity yielded positive outcomes. An even better performance was inhibited by political unrest in both Nigeria and Kenya, two leading markets in the territory. EBITA however declined 10% to R122 million as margins were pressured by an increased investment in sales representatives and regulatory support, relative currency weakness in the territory and by a shift in sales mix. Prospects The South African pharmaceutical business has the most comprehensive product offering in the country and leads the industry in both the private and public sectors. Focus will remain on extensive sales representation and promotional support driving consistent organic growth supplemented by regular new introductions to the market from the prolific product pipeline. Aspen will implement the 5.8% Single Exit Price increase granted by the Department of Health during March 2013, which will provide some relief to the margin pressure created by the weakening of the Rand and high-administered inflation. Aspen received a reduced share of the public sector ARV tender awarded recently and which has commenced on a phased basis. However, in achieving the largest allocation of the once-a-day triple combination, Tenofovir/Emtricitabine/Efavirenz, Aspen has secured supply of the product most favoured by clinicians as the first choice ARV treatment. Infant milk formula products are set to continue as the most important contributor to the performance of the South African Consumer division in the second half. The Asia Pacific business is expected to replace South Africa as the Group’s largest revenue generator by the end of the 2013 financial year as sales from the classic brands (a portfolio of 25 established pharmaceutical products purchased from Glaxosmithkline and distributed in Australia) add impetus to the second half performance. Aspen’s growing prominence in Australia and its unique offering spanning branded, generic and OTC medicines positions it well to outperform the market in this country. Demographic profile and regulator interventions limit growth prospects for the Australian market and Aspen is looking to build its influence in Asia to sustain the growth achievements of the Asia Pacific territory. Following the successful establishment of a subsidiary in the Philippines last year, Aspen will commence trade in Malaysia before the end of the financial year. Further countries in which Aspen can set up its own sales infrastructure in Asia are under consideration. Growth of the global brands portfolio and improved profit margins from this product range have been important drivers of the increased profit contribution from the International business. The Group is continuing to vigorously explore opportunities to expand the global brands portfolio by adding… Continue reading Aspen increases revenue to R9 billion

Renewal of Cautionary Announcement

Shareholders are referred to the cautionary announcement released by Aspen on 4 February 2013 (and subsequent renewals of this cautionary announcement) in which shareholders were advised of discussions between Aspen and MSD, known as Merck in the United States and Canada, in respect of a possible transaction comprising the acquisition of an active pharmaceutical ingredient facility situated primarily in the Netherlands and a related portfolio of pharmaceutical finished dose form products. These discussions remain ongoing and may have a material effect on the price of Aspen’s securities if successfully concluded and accordingly shareholders are advised to continue exercising caution when dealing in Aspen’s securities. Durban 3 June 2013

Aspen Trading Statement

APN – Aspen Pharmacare Holdings Limited – Trading statement Aspen Pharmacare Holdings Limited (Incorporated in the Republic of South Africa) (Registration number 1985/002935/06) Share code: APN & ISIN: ZAE000066692 (“Aspen”) Trading statement Aspen shareholders are hereby advised that, diluted normalised headline earnings per share (“DNHEPS”) from continuing operations, headline earnings per share and earnings per share for the 6 months ended 31 December 2012, are expected to exceed those reported in the comparative period, ended 31 December 2011, within the following ranges: Measure Range Notes DNHEPS from continuing operations  21% to 25% 1  Headline earnings per share  15% to 19% 2 Earnings per share  5% to 9% 3 Notes: 1. DNHEPS from continuing operations comprises diluted headline earnings per share adjusted for transaction costs, restructure costs and foreign exchange movements on transaction accounting. DNHEPS is the primary measure used by management to assess Aspen’s underlying operating performance. 2. The growth in headline earnings per share has been diluted by the effect of an increase in the weighted average number of ordinary shares in issue as a consequence of the conversion of 17.6 million preference shares into an equivalent number of ordinary shares on 28 June 2012. 3. The growth in earnings per share has been diluted as a result of capital profits on the disposal of discontinued businesses and products in the prior year and the effect of an increase in the weighted average number of ordinary shares in issue as a consequence of the conversion of 17.6 million preference shares into an equivalent number of ordinary shares on 28 June 2012. The financial results on which this trading announcement is based have not been reviewed or reported on by Aspen`s external auditors. Aspen`s interim results for the 6 months ended 31 December 2012 are scheduled to be published on SENS on 7 March 2013. Durban 21 February 2013 Sponsor: Investec Bank Limited

Cautionary Announcement – Discussions with MSD

ASPEN PHARMACARE HOLDINGS LIMITED (Incorporated in the Republic of South Africa) Registration number 1985/0002935/06 Share code: APN ISIN: ZAE000066692 (“Aspen” or “the Company”) CAUTIONARY ANNOUNCEMENT – DISCUSSIONS WITH MSD Shareholders are advised that Aspen is currently engaged in discussions with MSD (known as Merck in the United States and Canada) in respect of a possible transaction comprising the acquisition of an active pharmaceutical ingredient facility situated primarily in the Netherlands and a related portfolio of pharmaceutical finished dose form products. These discussions may have a material effect on the price of Aspen’s securities if successfully concluded and accordingly shareholders are advised to exercise caution when dealing in the company’s securities. Durban 4 February 2013 Sponsor Investec Bank Limited

Stephen Saad named as Business Leader of the Year

STEPHEN SAAD AWARDED BUSINESS LEADER OF THE YEAR TITLE Johannesburg: Aspen Group Chief Executive, Stephen Saad, was named as the Business Leader of the Year at the annual Sunday Times Top 100 Companies banquet last night. Durban-based Stephen, who graduated from the University of Natal in 1986 with a B.Com and later qualified as a Chartered Accountant, said: “We had a vision and we have pursued it with both perseverance and passion. I hope that our story inspires future generations of entrepreneurs. There is a wealth of opportunities to be harnessed both in and from South Africa. The rewards transcend material and personal benefits because the true dividends come from making a meaningful difference, uplifting people and helping them achieve goals that they believed were beyond their capability. Collectively we can deliver a better future for all South Africans.” Saad (48), co-founded Aspen Healthcare together with Gus Attridge, Aspen’s Group Deputy Chief Executive, and two other members in 1997. Since its establishment, Aspen has become the world’s ninth largest generic pharmaceutical company and Africa’s largest pharmaceutical manufacturer. Aspen is also the leading pharmaceutical company in South Africa, sub-Saharan Africa and Australia and a world leading manufacturer of generic anti-retrovirals (ARVs). With 18 manufacturing facilities at 13 sites on 6 continents, Aspen’s sustained unbroken performance of over 40% compound growth per annum of all key financial indicators has seen its share price from inception rise from 53c to over R156 at the time of the award. “Aspen’s success can be attributed to a number of factors, most notably innovation and leadership that practices a fine balance between passion and logic. Perseverance is a core quality at Aspen and our teams passionately embrace obstacles as challenges and deliver irrespective of the circumstances. We are also exceedingly proud of our South African manufacturing expertise and proved conventional wisdom wrong by showing that we can produce high quality products locally for global export,” said Saad. Aspen’s internationalisation has resulted in more than half of the Group’s revenue and profits being generated offshore and the success achieved in Australia following the acquisition of the Sigma pharmaceutical business in 2011 attests to astute leadership given that Aspen Australia’s profit has increased by many multiples in 18 months. Stephen said “one of Aspen’s greatest achievements of the past year was exporting Nelson Mandela Day internationally through our subsidiaries, with more than 2000 employees from 11 countries contributing to the success of 29 projects on 6 continents which touched the lives of some 3000 beneficiaries.” Through Aspen’s rapid global expansion strategy, the Group now employs 6000 people and has a presence in South Africa, Australia, Hong Kong, Philippines, Kenya, Tanzania, Uganda, Dubai, Germany, Ireland, Mauritius, Brazil, Mexico and Venezuela. Aspen supplies high quality, affordable medicines and products to more than 150 countries around the world. Stephen has driven Aspen’s Corporate Social Investment initiatives which focus on supporting programmes targeting the delivery of primary healthcare in rural areas, HIV/AIDS and TB programmes and healthcare education. In 2012 he raised more than R10 million for paediatric healthcare in Africa by cycling more than 240km off road in one day, an initiative that was supported by Minister of Health, Dr Aaron Motsoaledi. Stephen describes his overriding vision as: “Perseverance pays as to rest is to rust”. He is married and has four daughters.

Closed Period

Aspen is in a closed period from 1st January 2026 until the publication of the interim results on the JSE SENS platform on the 3rd March 2026.

The live presentation will take place in Cape Town at 08h30 on 2 March 2023.

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