APN – Aspen Pharmacare Holdings Limited – Trading statement Aspen Pharmacare Holdings Limited (Incorporated in the Republic of South Africa) (Registration number 1985/002935/06) Share code: APN & ISIN: ZAE000066692 (“Aspen”) Renewal of Cautionary Announcement Shareholders are referred to the renewal cautionary announcement released by Aspen on 7 March 2013 in which shareholders were advised of discussions between Aspen and MSD (known as Merck in the United States and Canada) in respect of a possible transaction comprising the acquisition of an active pharmaceutical ingredient facility situated primarily in the Netherlands and a related portfolio of pharmaceutical finished dose form products. These discussions remain ongoing and may have a material effect on the price of Aspen’s securities if successfully concluded and accordingly shareholders are advised to continue exercising caution when dealing in Aspen’s securities. Durban 23 April 2013 Sponsor: Investec Bank Limited