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APNASPENAspen Pharmacare Hldgs123190 (0.00%)

Aspen will be in a closed period from 1 January 2025 until the publication of the Interim Results on the JSE SENS platform on 3 March 2025.

Aspen Matrix Release

Aspen Pharmacare Holdings Limited (“Aspen”) and Matrix Laboratories Limited (“Matrix”) of the Republic of India, would like to announce the divestment of the existing joint ventures relating to the two chemical-manufacturing entities, Fine Chemicals Corporation (Proprietary) Limited (“FCC”) in Cape Town, South Africa and Astrix Laboratories (“Astrix”) Limited in Hyderabad, India. Aspen will acquire 50% of FCC from Matrix and, in turn, dispose of its 50% share in Astrix to Matrix. Aspen will retain a shareholding in Astrix through a B-share. Aspen and Matrix have secured a long-term supply agreement for the continued supply of anti-retroviral (”ARV”) active pharmaceutical ingredients. Furthermore, Aspen has acquired the rights to distribute a number of new generation ARV combination products into the South African and African markets. Stephen Saad, Group Chief Executive of Aspen said, “Aspen has retained all of the commercial rights and strategic advantage it previously enjoyed through Astrix, including priority of supply and maintenance of existing transfer pricing philosophies for ARVs, in both the revised shareholders agreement and various long term supply agreements. In addition Aspen has secured exclusive rights to a number of novel ARV combinations for South Africa. The arrangements will ensure the sustainable continuation of a successful long-term partnership in the fight against HIV AIDS. Matrix has secured and retained Aspen as a key customer and business partner. With outright ownership of FCC we will be seeking to achieve a more effective vertical integration of this business into the Aspen Group.” The agreement is subject to precedent conditions, including regulatory approval of the transactions. About Aspen: Aspen is the largest generics manufacturer in the southern hemisphere and it is also the leading supplier of generic medicines to both the private and the public sectors in South Africa. Aspen is the leading provider of ARVs to the private and public sectors in South Africa. Aspen produces more than seven billion tablets and capsules per annum and has the manufacturing capability to produce a diverse range of generic and specialized products. Aspen’s extensive basket of branded, generic, over-the-counter, FMCG, personal care and nutritional products is renowned for its quality, efficacy and affordability. Aspen has international operations in Australia, Latin America, East Africa, India and Mauritius. Aspen’s products are distributed in more than 100 countries around the world. Issued By: Roshni Gajjar, Aspen Investor Relations Tel: +27 (031) 580-8649 : Cell: +27 82 789 1826 On Behalf of: Stephen Saad, Aspen Group Chief Executive Gus Attridge, Aspen Deputy Group Chief Executive

Aspen establishes its international platform for future growth

Johannesburg – JSE listed Aspen Pharmacare Holdings Limited, Africa’s largest pharmaceutical manufacturer, is pleased to announce positive results for the year ended 30 June 2008. The Group delivered sustained growth from its existing bases in South Africa, Australia and Asia. A series of significant transactions were concluded to expand the Group’s footprint into Latin America, East Africa and more than 100 new markets globally. This sets the platform for a new growth trajectory. GROUP PERFORMANCE: • Group revenue increased by 21% to R4.9 billion (R4.0 billion). • Group operating profit improved by 14% to R1.2 billion (R1.1 billion). • Group earnings per share increased by 19% to 245.3 cents (205.7 cents). • Group headline earnings per share (HEPS) grew by 10% to 231.3 cents (210.1 cents). Stephen Saad, Aspen Group Chief Executive said, “Aspen has retained its leadership position in the South African market, while the Group has increased its presence in emerging markets with particular growth in the southern hemisphere. In addition, Aspen’s worldwide product portfolio has been expanded by the addition of four established branded products from GlaxoSmithKline (“GSK”) and an investment in an oncology franchise.” SOUTH AFRICAN OPERATIONS CONTINUE TO LEAD THE MARKET The South African business grew revenue by 15% to R3.8 billion and increased operating profit to R1.1 billion. The Pharmaceutical division recorded satisfactory revenue growth of 17% at R2.8 billion, amidst increasing pricing pressures, adverse economic conditions, sharp rises in the cost of materials and legislative challenges. The annual single exit price increase of 6.5% was granted in May 2008, four months later than anticipated. Closure of Chinese raw material facilities ahead of the Beijing Olympics led to a worldwide shortage of raw materials resulting in sharp base price increases which impacted the cost of manufactured goods. The Consumer division increased revenue by 9% to R950.9 million. Despite heightened competition and challenging market conditions, Aspen continued to be the preferred supplier to the public sector. More than 70% of the volumes in the South African government’s anti-retroviral (“ARV”) tender, awarded in June 2008, were secured, providing further evidence of Aspen’s international competitiveness. A SURGE OF ACTIVITY IN ASPEN’S INTERNATIONAL OPERATIONS Aspen Australia continued its impressive record of growth with revenue up 39% to R708.9 million and EBITA up by 34% to R95.7 million. In a market which faces price cuts, Aspen Australia delivered organic growth through innovative management, making it the sixth largest pharmaceutical company in Australia in terms of the number of Aspen products prescribed. Indian-based ARV active pharmaceutical ingredient (“API”) producer, Astrix, benefitted from the rise in demand for ARV’s. Astrix’s revenue doubled to R198.8 million with EBITA growing proportionally to R47.3 million. Aspen increased its presence in emerging markets with the conclusion of deals in Latin America and East Africa. In March Aspen acquired 50% of the Latin American businesses from Strides which are situated in Brazil, Mexico and Venezuela. This holding has since been raised to a controlling interest of 51%. In May 60% of Shelys Africa was purchased, providing access to the Tanzanian, Kenyan and Ugandan markets. Close to year-end, Aspen announced two watershed deals with leading multinational GSK. Four branded products, namely, Eltroxin, Imuran, Zyloric and Lanoxin, were acquired for GBP170 million, giving Aspen access to more than 100 new global markets. In a subsequent deal, a licensing and supply agreement was signed whereby GSK will source a range of generic products from Aspen and its Bangalore-based joint venture, Onco Therapies (“Onco”), for distribution into its developing markets. Onco will commence commercialisation of specialist oncology and generic products in 2010. COMMITTED INVESTMENT IN MANUFACTURING CAPABILITY The Group’s investment in manufacturing capabilities in South Africa continued during the year with capital expenditure of R379.3million. The upgrade to the Heritage Facility in Port Elizabeth is progressing according to schedule and is aimed at maintaining pace with increasing international production standards as well as adding capacity. The US Food and Drug Administration-accredited Oral Solid Dosage Facility, underwent further expansion to unlock additional capacity to meet increased domestic and export demand. The Sterile Facility is in the process of being validated with the commercialisation of eye drops for export into the US market expected during the first half of 2009. PROSPECTS As a consequence of the Group’s transformation during the past twelve months profits from international operations are expected to more than double during the forthcoming year. The international business currently contributes 16% to the Group’s operating profit. In spite of moderate growth from the South African business, the Pharmaceutical division is favourably positioned as the market leader in both the private and the public sectors. A healthy product pipeline has the potential to further accelerate performance. As South Africa’s generics brand of choice, Aspen is suitably positioned to benefit from the local and emerging market switch to quality generics. Increased manufacturing capabilities, a credible international presence and a diverse portfolio of products bodes well for continued growth prospects. Pricing pressures, legislation and inflationary factors continue to pose challenges to the pharmaceutical industry in general. Aspen will mitigate and manage these risks through new procurement initiatives, efficient commercial management and proactive engagement with legislators. Since its listing in 1998, Aspen has delivered an unbroken growth trajectory in both revenue and EBITA at a compound annual growth (CAGR) of 52% and 58% respectively. Shareholders have shared in this success through a CAGR of 50% in HEPS over the last ten years. The Group has embarked on a path of internationalisation by the successful conclusion of a number of strategic transactions over the past year. The acquired businesses and products add immediate value to Aspen’s earnings potential, supported by an established infrastructure which should enable growth to be sustained into the next decade. Issued by: Shauneen Beukes, Shauneen Beukes Communications Tel: +27 (012) 661-8467 : Cell: +27 82 389 8900 On Behalf Of: Stephen Saad, Aspen Group Chief Executive Tel: +27 (031) 580-8603 : Cell: +27 83 303 4833 Gus Attridge, Aspen Deputy Group Chief Executive Tel: +27 (031) 580-8605 : Cell: +27… Continue reading Aspen establishes its international platform for future growth

Revision of Terms of Aspen`s Investment in Strides` Latin American Operations

Further to the announcement made on 20 November 2007, Aspen is pleased to announce that its wholly owned subsidiary, Aspen Global Incorporated (“Global”) has agreed revised terms with Strides Arcolab Limited (“Strides”), a pharmaceutical company registered in the Republic of India, in respect of certain aspects of Global’s acquisition of an interest in Strides’ Latin American operations (“the Latam Operations”). The revised terms provide for the acquisition of a further 1% in the Latam Operations with immediate effect as well as a revision of the put and call options previously concluded. Hereafter this is referred to as “the Transaction”. With effect from 1 March 2008, Global acquired a 50% interest in the Latam Operations for an initial investment of US$152.5 million. Global will now acquire an additional 1% interest in the Latam Operations via the acquisition of shares from Strides for US$ 2.8 million. Global will thereby acquire management control. In terms of the agreement Global will also acquire the rights to 100% of the profits and dividends of the Latam Operations. In terms of the revised put and call options, Global has the right to acquire, and Strides has the right to sell to Global, Strides’ remaining 49% interest in the Latam Operations based on multiples of the EBITDA for the year ending 30 June 2009. The multiples are such that the effective purchase consideration for the entire share capital of the Latam Operations will amount to 9.32 times the EBITDA up to US$11.94 million plus 11.18 times the EBITDA over US$11.94 million. The maximum total effective consideration remains at US$ 333.5 million and would be payable if an EBITDA of US$31.8 million is achieved. The EBITDA is subject to adjustment such that it excludes the results of new acquisitions. The Transaction will be funded from existing cash resources.

Aspen Businesses in Licensing Deal With GSK

Johannesburg – JSE listed Aspen Pharmacare Holdings Limited (Apn) has announced today that it has entered into licensing and supply agreements with leading multinational pharmaceutical corporation, GlaxoSmithKline (“GSK”). In terms of the agreements Aspen will license intellectual property and supply finished dosage form pharmaceuticals to GSK through Aspen Group companies including Onco Therapies Limited (“OTL”), Aspen’s 50% owned joint venture with Strides Arcolab Limited (“Strides”) of India. The licensing and supply agreements are for emerging market territories excluding Sub-saharan Africa and India. Aspen and OTL will recover intellectual property development costs from GSK in addition to sharing profits with GSK from the commercialization of the products. Stephen Saad, Aspen Group Chef Executive said “We see this as a great opportunity to extend the worldwide reach of the Aspen business benefiting from GSK’s excellent strength in branding and marketing. GSK will achieve effective distribution for products in many countries which Aspen is presently unable to reach. This deal further endorses the quality of Aspen’s development of intellectual property and its manufacturing capabilities. The inclusion of the OTL joint venture adds an additional dimension to the products we have been able to offer to GSK and I would like to commend the significant contribution from Strides in this regard.” The first of the products commercialised under this arrangement is expected to be launched in 2010. Aspen Overview South African-based JSE-listed Aspen is Africa’s largest pharmaceutical manufacturer and a major supplier of branded and generic pharmaceutical, healthcare and nutritional products to southern Africa and selected international markets. Aspen has businesses in, inter alia, South Africa, Australasia, India, East Africa, and also exports to many other territories across the globe. Aspen’s 50% shareholding in Strides Latina provides for a Latin American presence in Brazil, Mexico and Venezuela. In June 2008 Aspen acquired four core branded GlaxoSmithkline products namely Eltroxin, Imuran, Lanoxin and Zyloric. This deal provides Aspen with access into more than 100 countries globally. Aspen is acknowledged as the largest generics manufacturer in the southern hemisphere and it is also the leading supplier of generic medicines to both the private and the public sectors in South Africa. Aspen is one of the top twenty generic manufacturers worldwide and South Africa’s number one generic brand. Aspen is also a leading global player in generic anti-retrovirals. Aspen produces more than six billion tablets and capsules per annum and it also manufactures liquids, creams and others products. Aspen’s extensive basket of branded, generic, over-the-counter, FMCG, personal care and nutritional products is renowned for its quality, efficacy and affordability. Aspen’s substantial and ongoing investment in its manufacturing facilities has positioned the Group optimally to manufacture and supply a vast range of products across a number of continents.

Aspen Invests R2.7 Billion in Expanding Global Business

Johannesburg – JSE listed Aspen Pharmacare Holdings Limited (Apn) has announced an investment by its offshore subsidiary, Aspen Global Incorporated, of GBP 170 million (approximately R2.7 billion) for the acquisition of four pharmaceutical products from GlaxoSmithKline (GSK). Aspen Global has acquired the intellectual property rights to the branded pharmaceuticals Eltroxin, Imuran, Lanoxin and Zyloric for all major markets worldwide with the exception of the USA and Zyloric in Japan. The deal substantially expands Aspen’s international business with the four products presently generating in excess of R1 billion in sales annually. Stephen Saad, Aspen Group Chief Executive said “This landmark transaction accelerates our strategy of global expansion, while simultaneously adding specialist and differentiated products to complement our existing vast product portfolio. We are confident that Aspen’s global distribution network will continue to supply these important products to patients across the world and we look forward to further expanding on the range of Aspen products marketed internationally through this network.” This transaction bodes well for Aspen’s globalization initiatives, building on their recent Latin American and East African investments. Aspen currently has affiliates in Asia, Australasia, Latin America and East Africa. The deal extends Aspen’s reach into major markets such as Japan and Europe. Stephen Saad said “This is a really exciting deal for Aspen which fits perfectly with our international expansion plans and should provide manufacturing opportunities for the Group in the future. The transaction has been made possible by the mutually beneficial and valued relationship which the Aspen Group has enjoyed with GSK over a number of years.”. The four products enjoy strong brand presence across more than 100 countries. Eltroxin is indicated for the treatment of hypothyroidism; Imuran is an immunosuppressant indicated, inter alia, for the survival of organ transplants; Lanoxin is indicated for certain heart conditions including heart failure; and Zyloric is administered for the treatment of gout. GSK will continue to manufacture these complex products for Aspen under terms of an initial supply agreement. The transaction also makes provision for a transitional distribution arrangement with GSK. Aspen currently markets a number of GSK prescription products into the South African market. Aspen Australia also holds the licence to market and distribute a portfolio of GSK products into the Australian OTC market.

Aspen wins significant portion of ARV tender

In addition to maintaining the supply contract for existing tender items, Aspen has also secured volumes for two new products, Aspen Efavirenz and Tenofivir. Tenofivir is a key new molecule to the ARV tender. Increased usage is anticipated over the tender period. Aspen secured more than 50% by volume of the entire ARV tender based upon expected future demand as published in the invitation to tender. Aspen’s share of the ARV Tender award included the following: Product/ Percentage won Efavirenz 600mg tablets 30% Stavudine 15mg tablets 100% Stavudine 20mg tablets 100% Stavudine 30mg tablets 80% Zidovudine 300mg tablets 60’s 100% Zidovudine 100mg capsules 100’s 100% Zidovudine 200ml syrup 100% Zidovudine 20ml syrup 100% Lamivudine 240ml syrup 100% Lamivudine 150mg tablets 80% Nevirapine tablets 100% Nevirapine suspension 100% Lamzid tablets 100% Tenofivir tablets 100% The South African ARV Tender is the largest of its kind in the world. Since inception, Aspen has been the major supplier to this programme. With the growing number of HIV/AIDS patients under treatment, the actual volumes supplied to the State during the last tender has continued to show incremental growth each month. Aspen has been able to respond to this growth in demand. Aspen produces the ARV products at its South African facilities, based in Port Elizabeth. Recent investments have been made in extending manufacturing capability and upgrading existing facilities. This has resulted in unlocking capacity and ensuring that demand requirements are met. The positive tender results confirm Aspen’s position as a competitive, reliable and valued supplier to the State. In his response to the ARV Tender results, Aspen Group Chief Executive, Stephen Saad said: “The results reflect positively on our competitiveness, breadth of our product offering and on the effectiveness of our service delivery. Aspen has its roots firmly in South African soil and is proud to be a leading contributor to healthcare in South Africa.

Shelys Africa Limited

Aspen Pharmacare Holdings Limited is pleased to announce the conclusion of a deal for the acquisition of 60% of the share capital of Shelys Africa Limited, with operations in East and Central Africa with effect from 01 May 2008. Shelys Africa Limited is the holding company of a group of East African pharmaceutical companies (“the Shelys Group”). The principal operations include Shelys Pharmaceuticals in Tanzania and Beta Healthcare International in Kenya. The Shelys Group reported consolidated revenue of USD 38 million for 2007. Shelys Pharmaceuticals was established in 1984 and holds a strong position in the Tanzanian market. Products are currently exported into other parts of East and Central Africa and initiatives are in place to expand further into the Central African market. The manufacturing facility in Dar-es-Salaam has recently been upgraded and is capable of manufacturing solids, liquids, capsules and penicillins. Shelys Pharmaceuticals’ diverse product portfolio covers key therapeutic groups, including: Pain and fever management Coughs and Colds Anti-malarials Antibiotics/Antimicrobials; and Contraceptives. Beta Healthcare has its origins with UK’s Boots International and joined the Shelys Group in 2003. The company has a product portfolio comprising predominantly of OTC’s and some branded pharmaceutical products. Beta Healthcare’s domestic customer base is spread throughout Kenya. Export sales are generated from other parts of East and Central Africa, including Tanzania, Uganda, Rwanda and Congo. The Shelys Group offers good manufacturing capabilities and a strong brand presence in the Central and East African regions. The group’s product offering is complimented by Aspen’s diverse product range and its strong distribution network facilitates immediate access into large parts of East and Central Africa. Furthermore, Aspen is able to offer extensive manufacturing and commercial expertise to the Shelys Group. The deal creates a tremendous opportunity for Aspen to leverage its strengths and extend its reach into Africa. This is aligned to the stated objective of providing quality, affordable medication throughout Africa. Aspen Group CEO, Stephen Saad, stated: “We are proud to have formed a strategic partnership with an established pharmaceutical leader in Africa. The Shelys Group shares our views on healthcare for Africa and offers excellent distribution capabilities”. Shelys Africa Group Chairman, Mr Jayesh Shah, commented that the tie up with Aspen would create a formidable group in the pharmaceutical sector in the East and Central African region and that this partnership would allow Shelys to greatly benefit from Aspen’s wide product range, technical expertise and market coverage.

Motivation, direction and structure!

After my interview with him it once again dawned on me how important it is to enjoy what you do; to have a passion for it; to be motivated! In fact, when I carefully reflect on all the interviews with great leaders the recipe for success becomes clearer and clearer: You have to have motivation, direction and structure in your own life and in the business or division that you lead! If you don’t have something that motivates you to be successful you will never reach what a Saad reached! This does not mean you are not successful if you don’t build a multi billion rand empire. But, if you want to be the best you can be in your specific job, business or industry you have to have a strong motivator, reason, or purpose! Something that drives you harder than anything else out there! This could range from a fanatic fear of failure or a burning desire for recognition to a passion for making a difference. It could even be an indescribable hunger for wealth because of a poor upbringing! The motive can be of a ‘positive’ or ‘negative’ nature, but it must be there! Notice the words fanatic, burning, passion, indescribable hunger? Somehow you have to have this or you will wobble at the first bump or curve in your road to success! This is a guarantee! Then there is Direction. When I asked Saad to give advice to small business owners that want to become really successful he suggested they have a plan, a goal, control expenses and stay positive. He added that no plan can be cast in stone so one must be flexible. In an interview with Laurie Dippenaar of First Rand Bank last week he also suggested that thinking long term is important. To have a plan and a goal or to think long term is directional! Simply being motivated is not enough! The motivation will fade if you don’t strengthen it with sound and believable directions, actions, plans! During the interview one often hears Saad say “I/we had a plan to…” This presupposes that he spends time and energy thinking through situations; evaluating what he should do about them. Remember previous articles where I explained that great leaders are excellent evaluators and doers? Following closely on direction is the importance of structure or structural elements of your life or business. This is where the detail lies and often the cause of most of our problems or challenges. In fact this is where the ‘expenses’ of the business or even your life lie. This is the area of life that needs ‘controlling’ as Saad suggested. If this area of your life or business spins out of control it affects your or those you lead’s motivation. If you cannot successfully manage structures make sure you have someone that can! One gets the impression that Saad has motivation, direction and structure both in his personal life and in his business. Because of this it almost felt out of place to ask him what price he has paid to get to where he is today? He is happy and organized, I believe. Of course he is not perfect, but he has simply learnt to apply the law of movement very successfully! The law of movement states that “all movement in life is governed by the integration of motivation, direction and structure”. If you want to excel in life learn to implement the law of movement successfully! Go on the “I to We” journey I explored the principle of ‘when enough is enough’ with Saad. He believes their company is ‘good’ but it is not great yet! As a Durban boy he believes “to rest is to rust” so you have to keep moving. And Aspen has indeed moved from small beginnings to more than 13 billion market cap; 100 staff to 3000; national to international; and so on! Why go on? This too is a characteristic of exceptional leaders – they are never truly satisfied!! They continue raising the bar; lifting the standard; expecting more! Saad says they have demonstrated so much in South Africa, but to be great they have to demonstrate it all internationally as well! In their beginning stages great leaders are never satisfied with what they themselves accomplish, so they keep raising their own bar; lifting their own standards; expecting more from themselves. Then they start projecting this attitude on others around them. The focus shifts from themselves to others; from ‘I to We’. They get excited about others reaching their potential as opposed to them reaching their potential. Their lives start revolving around assisting others to raise their bars; lifting their standards; expecting more of themselves. The irony of course is that in doing this they keep lifting themselves to higher levels! There are unfortunately those leaders whose focus never shifts from themselves; they keep pushing others to make themselves look better and better. Of course such individuals are leaders but not great leaders in my book. Aspen grew at a tremendous pace and during this time some of the hardest lessons learned by Saad were to manage people in different structures. He comments that in a small business you can be all things to all people – making all the calls and decisions, walking into the warehouse and doing the stock count. But, when the business gets larger you have to learn to let go and you have to learn and understand structures. To understand structures he tried to make a big business into a smaller business by breaking it into blocks, giving smaller areas of responsibility so that people could be accountable. In fact, what this did was to create more structures where leaders had opportunities to improve, raise the bar, lift the standards, and expect more. What gives this leader a real thrill is running and operating the business; achieving things! He says: “When everyone had given up on manufacture in SA; when the consensus view was that… Continue reading Motivation, direction and structure!

Closed Period

Aspen is in a closed period from 1 January until the publication of our interim results on the JSE SENS platform scheduled to be released on 1 March 2023.

The live presentation will take place in Cape Town at 08h30 on 2 March 2023.