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Aspen is in a closed period from 1st January 2026 until the publication of the interim results on the JSE SENS platform on the 3rd March 2026.

Press Releases

Accolades

French National Order of Merit conferred on Aspen’s Stephen Saad

Pretoria – The Chevalier de l’Ordre national du Mérite (Knight of the French National Order of Merit) was bestowed upon Stephen Saad, Aspen’s Group Chief Executive, at the University of Pretoria earlier today.  The national order, originally announced on 11 March 2019, was presented by President Emmanuel Macron at a small event with limited guests in attendance, given heightened Covid-19 gathering protocols.  The National Order of Merit, as awarded by the French President, recognises services and contributions rendered to France, and was created in 1963 by President Charles de Gaulle. Foreigners who have distinguished themselves by their merits in relation to France may be awarded a distinction in the National Order of Merit on the proposal of the Minister of Foreign Affairs and within the limits of specific quotas fixed by decree for a period of three years.  President Macron said, “It gives me great honour to bestow the insigna of Chevalier de l’Ordre national du Mérite upon Stephen Saad, in recognition of his role in developing the economic relations between France and South Africa, as well as his life-long engagement with initiatives that have benefited underprivileged communities across the world.”  Responding to President Macron, Stephen Saad said, “I am deeply humbled and honoured to be recognised with this presentation and I wish to thank President Macron, the French and South African governments for enabling Aspen to contribute towards economic development between our countries. The national order conferred on me is, however, humbly accepted on behalf of Aspen’s employees who have contributed in various roles towards this recognition, most notably our employees in France who take responsibility for the production and commercialisation of our sterile medicines at our manufacturing site in Notre Dame de Bondeville, Normandy. These employees have, despite the many challenges experienced over the last year as a result of the Covid-19 pandemic, remained dedicated to providing healthcare solutions to patients through their expertise, knowledge and passion.”  “Our sterile products produced at the Notre Dame de Bondeville site have, along with a number of other Aspen medicines, played a critical role in treating patients suffering from Covid-19 across Europe and elsewhere in the world. The French government has supported Aspen’s investment and manufacturing initiatives in France since our acquisition of this site in 2013 and we express our sincere thanks to France and its people.” 

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Press Releases

Aspen Joins South Africa in Mourning Dr Sindi Van Zyl

Aspen joins the country and the medical fraternity in mourning the passing of Dr Sindi van Zyl, a dedicated and significant contributor to our country’s healthcare system. Dr Van Zyl will always be remembered for her ongoing involvement in helping our country in fighting the HIV/AIDS pandemic as a compassionate doctor and, an HIV clinician. Affectionately known as ‘the People’s Doctor’, her mission was to make medicine relatable and understandable to all citizens, including Aspen’s employees, through several presentations during events such as our annual World AIDS Day Celebrations. Aspen is also inspired by Dr Van Zyl’s legacy in response to previous pandemics and her continued efforts in helping HIV+ patients in fighting the current pandemic. We extend our deep and sincere condolences to her husband, two beautiful children and her family, and we reinforce our previous commitment in assisting the family with her medical fees. Lala kahle Dokotela.

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Aspen welcomes President Ramaphosa and his delegation to Aspen’s world class sterile manufacturing facility

Gqeberha, South Africa – Aspen, a global multinational specialty pharmaceutical company, earlier today hosted President Cyril Ramaphosa and an accompanying government delegation at its flagship manufacturing site in the Eastern Cape. Aspen has invested in excess of R3.0 billion at this sterile manufacturing site, the single largest investment in the pharmaceutical industry in South Africa. The new sterile facility contains high-technology, state-of-the-art pharmaceutical equipment and systems that will be used to manufacture advanced sterile medicines, including vaccines.   These investments at the Gqeberha manufacturing site, which has been a cornerstone of both local ARV and MDR TB manufacture, demonstrate Aspen’s ongoing and enduring commitment to South Africa and the continent. With roots firmly embedded in African soil, a continent which carries a disproportionately high disease burden, the investment in advanced pharmaceutical technology enables Aspen to continue to contribute to improved access to treatment, respond to public health emergencies and to create significant economic, export and job creation opportunities. This facility will allow Aspen to manufacture multiple and complex sterile products, such as vaccines and Aspen’s global anaesthetics. It will also ensure quality and security of both domestic and international supply.  As South Africa and the world grapples with the management of the COVID pandemic, this strategic investment will materially contribute to the management of this pandemic. Through the collaboration announced between Aspen and Johnson & Johnson, Aspen is the only manufacturing site on the African continent and in the southern hemisphere selected by Johnson & Johnson to compound, fill, finish and package the Janssen (a Johnson & Johnson company) COVID-19 vaccine. Aspen and Johnson & Johnson’s commitment to Africa is further underpinned by continued collaboration to enhance the amount of vaccines produced at this facility, with most of the production serving the needs of Africans. We are very proud and grateful to have the opportunity to partner with one of the world’s largest and most technologically advanced healthcare companies who has committed to ensuring equitable access to COVID-19 vaccines. This has been demonstrated through their actions and was fundamental in our considerations of which company to partner. The Aspen and Johnson & Johnson project teams responsible for the technical transfer process at the new sterile facility, worked tireless ensuring collaboration in keeping to the ambitious goals and beating timelines. During this time, the Aspen project team have strengthened their technical competencies, complementing the capabilities of these highly skilled Aspen employees and enhancing a knowledge base in South Africa that will contribute to further solving future public challenges. Most of the vaccines manufactured at this Aspen’s new sterile facility in 2021 will be supplied to South Africa and the member states of the African Union.  The South African government agreement with Johnson & Johnson, is to deliver more than 30 million doses of the Janssen COVID-19 vaccine to South Africans, with the first deliveries being made in April 2021. The African Union is expected to receive over 400 million doses. Addressing delegates at Aspen’s sterile facility in Gqeberha, H.E. President Cyril Ramaphosa said, “We are here to see how we can save lives. I am pleased to inform you that Johnson & Johnson has agreed to make 250 million vaccines available to Africa with 30 million for South Africans.  Coming here to this facility in Gqeberha has been an honour. Aspen belongs to us as South Africans and it is making life saving vaccines and we as South Africans must be in pole position to receive these vaccines and for them to be made available to the continent immediately. We are pleased of what we have seen here and the commitment of Aspen’s people. This world class facility is in another league and I congratulate Aspen on this facility to manufacture vaccines for our country and for our continent. I would also like to congratulate Aspen on living up to their promise of investing more than R3 billion in our country.”  Stephen Saad, Aspen Group Chief Executive said, “This is a watershed moment for Aspen as we continue to implement our strategic vision of delivering quality, affordable medicines using high-technology pharmaceutical equipment, contributing to improved health outcomes. This vision has come with much sacrifice and perseverance however we have been rewarded through the endorsement of the relevance of our product portfolio and capital investments at our manufacturing facilities. Our sterile capacity is a big step to ensuring that Africa has both the capacity and capabilities to reduce its reliance on other countries in addressing its healthcare priorities. The manufacture of the Janssen COVID-19 vaccine builds on the global contributions we have made with both our anaesthetics portfolio and dexamethasone supply. We are particularly proud that this vaccine manufacture is taking place in Africa. We hope that our success will inspire and give confidence to others to further invest in our continent. We have set ourselves a further target to become the pandemic solution for Africa. Security of supply for Africans is best achieved through African facilities. Aspen intends to assist with this goal by targeting further enhancement of capacities on the existing sterile footprint to ensure that we have the capabilities to give one liquid dose of vaccine per African person.” “Finally, with all the capacities and investments, this could not have been achieved without the dedication, commitment and passion of the Aspen and Johnson & Johnson technical teams. To each and every one of you, we at Aspen, in fact every citizen of our continent and millions more across the globe owe you a massive debt of gratitude. You are our heroes. Thank you, Nkosi sikelel’ iAfrika.” Premier Oscar Mabuyane said, “The commitment for this investment was made at the Investment Conference initiated by President Cyril Ramaphosa in 2018, where Aspen announced plans to invest 3.4 billion in our province to manufacture sterile anaesthetics, a niche and high tech manufacturing capability that presents both domestic and export opportunities. We view their investment as the fruits of President Ramaphosa’s leadership and the confidence of social partners to the direction he is leading the country to.” “At that time Aspen made

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Stephen Saad, Aspen Chief Executive address to President Ramaphosa and his delegation at Aspen’s flagship manufacturing site in Gqberha, Eastern Cape

“Our Aspen philosophy has always been to give purpose to life. This is best achieved by contributing meaningfully to others. Aspen has defined itself and continues to define itself as a company that serves humanity, particularly the most vulnerable amongst us. It was over a decade ago that we made a special announcement on a prior pandemic. Aspen had achieved a global first. The first tentatively approved FDA generic ARV. As a result, this site became the backbone of our country’s roll-out of ARVs, making product for millions of our patients monthly and saving so many lives from that pandemic. Patients we continue to support to this day. Today we are proud to share with you our contribution to the COVID pandemic. Aspen has invested in excess of R3.0 billion at this sterile manufacturing site, the single largest investment in the pharmaceutical industry in South Africa. The new sterile facility contains high-technology, state of the art pharmaceutical equipment and systems that will be used to manufacture advanced sterile medicines, including vaccines.   These investments demonstrate Aspen’s ongoing and enduring commitment to South Africa and the continent. With roots firmly embedded in African soil, a continent which carries a disproportionately high disease burden, the investment in advanced pharmaceutical technology enables Aspen to continue to contribute to improved access to treatment, respond to public health emergencies and create significant economic, export and job creation opportunities.  This facility will enable Aspen to manufacture multiple and complex sterile products, such as vaccines and Aspen’s global anaesthetics products. It will also ensure quality and security of both domestic and international supply.  As SA and the world grapples with the management of the COVID pandemic, it will also meaningfully contribute to the management of this pandemic. Through the collaboration announced between Aspen and Johnson & Johnson, Aspen is the only manufacturing site on the African continent and in the southern hemisphere selected by Johnson & Johnson to compound, fill, finish and package the COVID-19 vaccine. We are very proud and grateful to have the opportunity to partner with one of the world’s largest and most technologically advanced healthcare companies who has committed to ensuring equitable access to COVID-19 vaccines. This they have demonstrated through their actions and was fundamental in our own considerations of whom to partner. The Aspen and Johnson & Johnson project teams responsible for the technical transfer process at new sterile facility, worked tireless ensuring collaboration in keeping to the ambitious goals and even beating timelines.  During this time, the Aspen project team have strengthened their technical competencies, complementing the capabilities of these highly skilled Aspen employees and enhancing a knowledge base in South Africa that will contribute to further solving future public challenges.  The majority of the vaccines manufactured at this facility in 2021 will be supplied to South Africa and the member states of the African Union. The South African government has agreement with Johnson & Johnson, to deliver more than 30 million doses of the Janssen vaccine to South Africans, with the first deliveries being made in April 2021. The African Union will receive 400 million doses. This is a watershed moment for Aspen as we continue to implement our strategic vision of delivering quality, affordable medicines using high technology pharmaceutical equipment that contribute to improved health outcomes.  This vision has come with much sacrifice and perseverance. However, we have been rewarded through endorsement of the relevance of our product portfolio and capital investments in our manufacturing facilities. The manufacture of the Janssen COVID-19 vaccine builds on the global contributions we have made to COVID through sustained supply of both our anaesthetic portfolio and dexamethasone. We are particularly proud that this vaccine manufacture is taking place in Africa. Our sterile capacity is a big step forward to ensuring that Africa has both the capacity and capabilities to reduce its reliance on other countries in addressing the healthcare priorities on the continent. We hope that our success will inspire and give confidence to others to further invest in our continent.   At Aspen, we have set ourselves a further target to become the pandemic solution for Africa. Security of supply for Africans is best achieved through African facilities.  Aspen intends to assist with this goal by targeting further enhancement of capacities on the existing sterile footprint to ensure that we have the capabilities to give one liquid dose of vaccine per African person. A special thank you, to the President, SAHPRA and the Ministers of Health, Trade Industry and Competition and their departments for their unwavering support and commitment and in assisting us, by making this journey as seamless as possible. Finally, with all the capacities and investments, this could not have been achieved without the dedication, commitment and passion of the Aspen and Johnson & Johnson technical teams.  To each and every one of you, we at Aspen, in fact every citizen of our continent and millions more across the globe owe you a massive debt of gratitude. You are our Heroes  Thank you, Nkosi sikelel’ iAfrika.” 

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Aspen increases revenue by 17% to R18.6 billion

Johannesburg – JSE Limited listed Aspen Pharmacare Holdings Limited (APN), a global multinational specialty pharmaceutical company, has announced unaudited interim financial results for the six months ended 30 December 2021. Stephen Saad, Aspen Group Chief Executive said, “The business has delivered pleasing results and has proven to be in robust shape over the past six months. We are positioned to maintain the current positive momentum, provided we experience no further unexpected headwinds as a result of COVID-19. The past 12 months have been extraordinary, and Aspen has successfully navigated these turbulent times ensuring delivery of medicines to patients. During these challenging times, Aspen employees remained committed to contributing to the fight to combat the effects of the virus. We persevered with the build project to increase our sterile capabilities and capacity, we began the transfer of our Anaesthetics products to Aspen sites and remained steadfast in our commitment to patients and customers ensuring all manufacturing and commercial operations continued, uninterrupted.” COMMENTARY GROUP HIGHLIGHTS (CONTINUING OPERATIONS) Despite the many challenges arising from COVID-19, Aspen has maintained uninterrupted operations, including at our 15 manufacturing sites. This has been due to robust business continuity plans and, most importantly, the resilience and commitment of our employees. This has enabled us to continue to supply our medicines to patients in need across the world and to make an important contribution in assisting to combat the effects of the virus. Group revenue for the six months ended 31 December 2020 grew 17% to R18,6 billion following 12% and 36% increases by Commercial Pharmaceuticals and Manufacturing, respectively. Commercial Pharmaceuticals delivered revenue growth across all regions and revenue also advanced in each of the Manufacturing segments. Normalised EBITDA was up 11% to R5,2 billion as well controlled operating expenses partially offset both a lower gross profit percentage and lower other operating income. Normalised headline earnings per share (“NHEPS”) increased 16% to R6,76, benefitting from reduced net financing costs. Net borrowings declined to R27,7 billion from R35,2 billion at 30 June 2020. The reduction in net borrowings was supported by the upfront cash consideration from the completion of the divestment of the European Thrombosis assets and the relative strengthening of the ZAR. The leverage ratio, as at 31 December 2020, is 2,83 times against the banking covenant of 3,50 times. Operating cash flow was in line with our expectations, given the abnormally high inflows in the prior financial year. The outstanding consideration for the European Thrombosis assets, amounting to R7,0 billion, is receivable before the end of June 2021. This provides a further opportunity to reduce both debt and the leverage ratio. The table below compares performance from continuing operations in the prior comparable period at reported exchange rates and then at constant exchange rates (“CER”). The higher growth at reported rates is due to the weakening of the average rate of the ZAR over the reporting period against the majority of the other currencies in which Aspen trades. 1 Calculated in terms of the Facilities Agreement 2 EUR 389 million at Aspen’s 31 December 2020 exchange rate of ZAR 17,91 to EUR 1   Six months ended 31 December 2020 Continuing operations Reported H1 2021 R’million Restated H1 2020^ R’million Change at reported rates % Change at CER# % Revenue 18 633 15 984 17 6 Normalised EBITDA* 5 192 4 680 11 2 NHEPS** (cents) 676,2 585,1 16 7 ^ H1 2020 has been restated as a result of the discontinuation of operations in H1 2021. # The CER % change is based upon the performance for the six months ended 31 December 2019 restated using the average exchange rates for the six months ended 31 December 2020. *   Operating profit before depreciation and amortisation adjusted for specific non-trading items as defined in the Group’s accounting policy. **    NHEPS is HEPS adjusted for specific non-trading items, being transaction costs and other acquisition and disposal-related gains or losses, restructuring costs, settlement of product related litigation costs, net monetary adjustments and currency devaluations relating to hyperinflationary economies and significant once-off tax provision charges or credits arising from the resolution of prior year tax matters. DISCONTINUED OPERATIONS Discontinued operations for the six months ended 31 December 2020 include the European Thrombosis assets to date of disposal (being 27 November 2020), the costs relating to this disposal, related Thrombosis product discontinuations, other product divestments and the residual costs related to prior period disposals. Discontinued operations in the prior period includes the results of the operations classified as discontinued in the current period as well as those discontinued in the prior financial year, the most material of which was the Japanese Business. SEGMENTAL PERFORMANCE (CONTINUING OPERATIONS) Commercial Pharmaceuticals Commercial Pharmaceuticals, which comprises Aspen’s Regional Brands and Sterile Focus Brands, grew 12% (+4% CER) to R14,3 billion. Gross profit increased 8% (+1% CER) to R8,2 billion. The margin percentage was diluted by an unfavourable mix in Sterile Focus Brands as well as higher manufacturing and supply chain costs associated with the pandemic. Regional Brands Regional Brands revenue increased 7% (+1% CER) to R8,8 billion. COVID-19 continued to negatively affect demand for medicines treating communicable diseases, most notably in South Africa and Australia. Despite this, the affected regions of Africa Middle East (+2% CER) and Australasia (+4% CER) contributed to the growth of the segment with Asia (+6% CER) and Americas (+4% CER) also providing momentum. Gross profit percentage was marginally higher for the period at 55,8% in spite of the higher costs associated with operating under COVID-19 conditions. Sterile Focus Brands Revenue from Sterile Focus Brands increased 20% (+7% CER) to R5,6 billion, benefitting from improved supply and tender management. COVID-19 driven demand added to strong gains in Europe CIS (+19% CER) while Asia (+1% CER) finished above the pre-COVID sales levels recorded in the comparative period. A greater weighting of sales from lower margin products as well as higher costs associated with operating under COVID-19 conditions weighed on the gross profit percentage. Manufacturing Manufacturing revenue increased 36% (+17% CER) to R4,3

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Aspen concludes strategic partnership with US-based Avion Pharmaceuticals

Durban – United States-based Aspen Pharma USA Inc. and Aspen Global Incorporated, located in Mauritius, both wholly owned subsidiaries of Aspen Pharmacare Holdings Limited, have announced a license and commercialisation agreement with Avion Pharmaceuticals, LLC, a specialty pharmaceutical company, for the exclusive rights to relaunch Cenestin® in the USA. This is a New Drug Application (NDA), without any generics, of the plant-derived, synthetic complex conjugated estrogens product for the treatment of hot flushes, night sweats and other moderate-to-severe vasomotor symptoms associated with menopause. Stephen Saad, Aspen Group Chief Executive said, “Avion’s expertise and success in Women’s Health provides the perfect partnership to relaunch Cenestin®. The nine synthetic conjugated estrogens used in Cenestin® will be manufactured at our active pharmaceutical ingredient (“API”) site in Oss, the Netherlands. The relaunch of Cenestin® provides Aspen with an opportunity to increase our presence in the United States leveraging our niche global intellectual property. Avion is ideally positioned to execute the relaunch of Cenestin® given that they have the necessary technical and commercial resources to drive the sales and marketing of this product in the United States. Cenestin® will provide an effective alternative to millions of women wishing to manage the symptoms of menopause using nine plant-derived synthetic conjugated estrogens. The relaunch of Cenestin® could take place before our financial year end of 30 June 2021, subject to the standard approvals required by the US Food and Drug Administration.” Art Deas, CEO of Avion Pharmaceuticals said, “Avion Pharmaceuticals has been diligent and focused in supporting our patients and prescribing partners in Women’s Health for over 9 years with our portfolio of prescription nutritional supplements and oral contraceptives. Cenestin® will allow us to expand our commitment to women who are seeking options to manage their menopause journey and allow for effective symptom management.  We are honoured to support women throughout their life with their important health-related needs and milestones they encounter.” Cenestin® is the only plant-derived mixture of nine conjugated estrogens indicated for treatment of moderate to severe vasomotor symptoms and moderate to severe symptoms of vulvar and vaginal atrophy due to menopause. For the past few decades, the only complex conjugated estrogens product women could choose from was derived from pregnant mares’ urine. Cenestin® tablets will be available in 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg and 1.25 mg strengths of synthetic conjugated estrogens, A.[1] Vasomotor symptoms are prevalent  in approximately 40 to 50 million women in the United States[2], with approximately 1.3 million women becoming menopausal each year[3]. With the relaunch of Cenestin®, millions of menopausal women will have a plant-derived choice in conjugated estrogens products for the treatment of vasomotor symptoms associated with menopause. Cenestin® showed significant reduction in moderate to severe vasomotor symptoms at weeks 4, 8 and 12 as compared to placebo in a double-blind, placebo-controlled, randomized 12-week clinical trial of 120 postmenopausal women. Cenestin® significantly decreased the mean vaginal pH from baseline as compared to placebo in a 16-week, randomized, placebo-controlled, multicenter clinical study in 72 postmenopausal women. Cenestin® was observed to be well tolerated, safe and effective in both clinical studies. [1]   https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020992s034lbl.pdf [2] Utian WH. Psychosocial and socioeconomic burden of vasomotor symptoms in menopause: a comprehensive review. Health Qual Life Outcomes. 2005;3:47. [3] Menopause and Mood Disorders: Overview, Pathophysiology emedicine.medscape.com › article › 295382-overview

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Media Enquiries

Shauneen Beukes
Group Communications Consultant
+27 31 580 8600
+27 82 389 8900
sbeukes@aspenpharma.com

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Closed Period

Aspen is in a closed period from 1st January 2026 until the publication of the interim results on the JSE SENS platform on the 3rd March 2026.

The live presentation will take place in Cape Town at 08h30 on 2 March 2023.

Corporate

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